Römer 6:21

What fruit had ye then in those things whereof ye are now ashamed? for the end of those things is death--What permanent advantage, and what abiding satisfaction, have those things yielded? The apostle answers his own question:--"Abiding satisfaction, did I ask? They have left only a sense of 'shame.' Permanent advantage? 'The end of them is death.'" By saying they were "now ashamed," he makes it plain that he is not referring to that disgust at themselves, and remorse of conscience by which those who are the most helplessly "sold under sin" are often stung to the quick; but that ingenuous feeling of self-reproach, which pierces and weighs down the children of God, as they think of the dishonor which their past life did to His name, the ingratitude it displayed, the violence it did to their own conscience, its deadening and degrading effects, and the death--"the second death"--to which it was dragging them down, when mere Grace arrested them. (On the sense of "death" here, see on Rom 5:12-21, Note 3, and Rom 6:16 : see also Rev 21:8 --The change proposed in the pointing of this verse: "What fruit had ye then? things whereof ye are now ashamed" [LUTHER, THOLUCK, DE WETTE, PHILIPPI, ALFORD, &c.], seems unnatural and uncalled for. The ordinary pointing has at least powerful support [CHRYSOSTOM, CALVIN, BEZA, GROTIUS, BENGEL, STUART, FRITZSCHE]).

The apostle having at large asserted, opened, and proved, the great doctrine of justification by faith, for fear lest any should suck poison out of that sweet flower, and turn that grace of God into wantonness and licentiousness, he, with a like zeal, copiousness of expression, and cogency of argument, presses the absolute necessity of sanctification and a holy life, as the inseparable fruit and companion of justification; for, wherever Jesus Christ is made of God unto any soul righteousness, he is made of God unto that soul sanctification, Co1 1:30. The water and the blood came streaming together out of the pierced side of the dying Jesus. And what God hath thus joined together let not us dare to put asunder.

6:21 eternal doom (literally death): Throughout chs 5–8, Paul uses death to describe the eternal consequences of sin (5:12, 14, 15, 17, 21; 6:16, 23; 7:5, 9-10, 13, 24; 8:2, 6, 13). The language goes back to God’s warning to Adam and Eve (Gen 2:17). This death is not primarily physical death; it denotes separation from the fellowship of God that, if not reversed through faith in Christ, will last forever.